Frequently asked questions (FAQ): drug-induced deaths in Europe

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Page last updated: 29 August 2025

This page provides answers to the questions most often asked about drug overdose deaths in Europe. Also known as ‘drug-related deaths’ or more specifically ‘drug-induced deaths’, they are deaths directly attributable to the use of illicit drugs. The information presented here is based on the latest data from the 27 Member States of the European Union and the European Union Drugs Agency (EUDA) affiliates Norway and Türkiye. It draws on contributions from specialists from these countries, as well as on information provided by the countries in an annual reporting exercise.

Introduction

The latest European Drug Report (EUDA, 2025) estimated that around 7 500 deaths involving one or more illicit drugs were reported in 2023 in the European Union. This estimate rises to around 8 100 deaths when Norway and Türkiye are included. Men accounted for 4 out of every 5 drug-induced deaths. It should be noted that the data for 2023 are provisional and are an underestimate, due to reporting delays and other limitations in reporting capacity apparent in some countries.

All these deaths were premature, predominantly affecting people in their thirties and forties, representing decades of life lost.

Opioids, often heroin, were involved in two thirds of the drug-induced deaths reported in Europe, although this is not true for all countries. Opioids used in agonist treatment can also be found in post-mortem analyses in some countries. Deaths related to opioid medications, such as oxycodone and tramadol, are also reported. Available data from 16 EU Member States indicate that the number of deaths related to fentanyl and fentanyl derivatives remained relatively stable in 2023, the year with the most recent data, when the drugs were linked to 153 overdose deaths compared with 159 in 2022. Some of these fatalities might be associated with diverted medicines rather than with illicit fentanyl. Other potent synthetic opioids, notably nitazenes (identified since 2019), are involved in deaths in several countries, including Estonia, Finland, France, Germany, Latvia, Norway and Sweden, with peaks in the number of deaths reported in 2023-24 in these countries. Deaths related to stimulants such as cocaine and amphetamines have been reported in recent years in several countries. Most drug-induced deaths involve polydrug use. For all these substances, we expect that the presented numbers are an underestimation of the real numbers.

Aim and objectives

This page aims to provide answers to the main questions related to the nature and scale of the drug-induced deaths problem in Europe. Enhancing the monitoring and responses to these deaths is a priority of the European Union drugs action plan 2020-2025 and of the EUDA. These pages present the most recent epidemiological data and highlight the gaps in the information related to drug-induced mortality in Europe.

We are updating this page to mark International Overdose Awareness Day on 31 August 2025.

What this page contains

This page contains up-to-date information on drug-induced deaths in the 27 EU Member States, Norway and Türkiye, focusing on selected recent concerns and threats, the demographics (who is dying) and the time trends. It also summarises the common situations that increase the risk of drug-induced deaths and presents an overview of the current state of interventions aimed at preventing these deaths. In addition, background information is given on the methodology, the sources of information and their limitations, together with references and links to resources.

Questions

Emerging concerns and threats

Three concerns and potential threats are highlighted: the outbreaks of deaths linked to highly potent synthetic opioids, mainly nitazenes; deaths associated with the co-use of drugs and medicines; and the high and increasing proportion of drug-induced deaths with cocaine involved in some countries. More information on these three topics can be found in the drug-induced deaths section of the 2025 European Drug Report (EUDA, 2025).

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Risk factors for drug-induced deaths

There are identified circumstances and risk factors associated with drug-induced deaths. This section provides an overview of the evidence in this area. Special focus is given to overdose with suicidal intent among women, and to the needs of people in prison or being released from prison.

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Preventing drug-induced deaths

The use of illicit drugs is a considerable contributor to the global burden of disease. Interventions designed to reduce this burden include prevention activities, intended to reduce or slow the rate at which drug use may be initiated, and provision of treatment to those who have developed drug problems. A complementary set of approaches goes under the general heading of harm reduction. There is a range of evidence-based and integrated interventions available to reduce the risk of overdoses, including fatal overdoses. This section presents different strategies and approaches for reducing drug-induced deaths:

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Methodology

The Reitox national focal points and their experts in the 27 EU Member States, Norway and Türkiye report data annually to the EUDA through standard tables and workbooks. The annual Statistical Bulletin contains the most recent available data on the drug situation in Europe provided by the EU Member States, Norway and Türkiye. These data sets underpin the analysis presented in the European Drug Report. This section provides information on the methods, sources and definitions used to monitor drug-induced deaths in Europe, as well as the strengths and limitations of the surveillance in place. This section also provides methods and references to recently published findings on the overall mortality – due to drug-induced deaths and other causes – among people who use drugs.

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List of figures

A list of all figures in this publication is available below.

PDF version of this publication

This publication was designed as a digital-first product, structured by sections, and optimised for online reading. Within each chapter, you may download a PDF version of the page. We are also making available here  a PDF version of the full publication. Please note that some errors may have occurred during the transformation process and that it is possible that this version does not contain all corrections made since the report was first published (please check the last updated date).

Frequently asked questions (FAQ): drug-induced deaths in Europe PDF version

Resources and references

This section provides a selection of EUDA resources along with the details of the works cited in the text.

More information and resources

References

ARS La Réunion (2023), ‘Vigilance : Circulation d’une substance non identifiée à risque mortel [Vigilance: circulation of a non identified substances with deadly risk]’, Alerte sanitaire, Agence Régionale de Santé La Réunion, Agence Régionale de Santé La Réunion.

Blundell, M., Gill, R., Thanacoody, R., Humphries, C., Wood, D. M. and Dargan, P. I. (2024), ‘Joint RCEM and NPIS best practice guideline: assessment and management of acute opioid toxicity in adults in the emergency department’, Emergency Medicine Journal, doi:10.1136/emermed-2024-214163.

Colell, E., Domingo-Salvany, A., Espelt, A., Pares-Badell, O. and Brugal, M. T. (2018), ‘Differences in mortality in a cohort of cocaine use disorder patients with concurrent alcohol or opiates disorder’, Addiction 113(6), pp. 1045-1055, doi:10.1111/add.14165.

Daveluy, A., Perino, J., Gibaja, V., Le Boisselier, R., Batisse, A., Miremont-Salame, G., Peyre, A., Boucher, A., et al. (2025), ‘From regional signal to alert in addictovigilance’, Therapie 80(2), pp. 213-222, doi:10.1016/j.therap.2024.10.056.

Degenhardt, L., Larney, S., Kimber, J., Gisev, N., Farrell, M., Dobbins, T., Weatherburn, D. J. and Gibson, A. (2014), ‘The impact of opioid substitution therapy on mortality post-release from prison: Retrospective data linkage study’, Addiction 109(8), pp. 1306-1317, doi:10.1111/add.12536.

Degenhardt, L., Grebely, J., Stone, J., Hickman, M., Vickerman, P., Marshall, B. D. L., Bruneau, J., Altice, F. L., et al. (2019), ‘Global patterns of opioid use and dependence: harms to populations, interventions, and future action’, Lancet 394(10208), pp. 1560-1579, doi:10.1016/S0140-6736(19)32229-9.

Désesquelles, A., Kensey, A. and Meslé, F. (2018), ‘Circonstances et causes des décès des personnes écrouées en France: le poids écrasant des morts violentes’, Population 73(4 ), pp. 757-786, doi:10.3917/popu.1804.0757.

Edvardsen, H. M. E., Clausen, T., Bogstrand, S. T. and Skurtveit, S. (2025), ‘The role of prescribed opioids in Norwegian overdose deaths in 2005–2021’, European Journal of Clinical Pharmacology, doi:10.1007/s00228-025-03897-5.

Eide, D., Skurtveit, S., Clausen, T., Hesse, M., Mravcik, V., Nechanska, B., Rolova, G., Thylstrup, B., et al. (2023), ‘Cause-specific mortality among patients in treatment for opioid use disorder in multiple settings: a prospective comparative cohort study’, European Addiction Research 29(4), pp. 272-284, doi:10.1159/000530822.

EMCDDA (2010), The drug-related deaths (DRD) standard protocol, version 3.2, EMCDDA, Lisbon.

EMCDDA (2012), Mortality among drug users: guidelines for carrying out, analysing and reporting key figures, 2011–12.

EMCDDA (2015), Mortality among drug users in Europe: new and old challenges for public health, EMCDDA Papers.

EMCDDA (2017), EMCDDA assessment of drug-induced death data and contextual information in selected countries, EMCDDA, Lisbon.

EMCDDA (2019a), Drug-related deaths and mortality in Europe: update from the EMCDDA expert network, Rapid Communication, Publications Office of the European Union, Luxembourg, doi:10.2810/627691.

EMCDDA (2019b), An analysis of post-mortem toxicology practices in drug-related death cases in Europe, Technical reports, Publications Office of the European Union, Luxembourg, doi:10.2810/81554.

EMCDDA (2021a), ‘Prison and drugs in Europe: current and future challenges’, Insights, 25, Publications Office of the European Union.

EMCDDA (2021b), ‘Drug-related deaths (DRD) in Europe: updates from the annual meeting of the EMCDDA DRD expert network 30 September – 1 October 2021’, EMCDDA, Lisbon.

EMCDDA (2021c), Polydrug use: health and social responses.

EMCDDA and Europol (2022), EU drug market report: cocaine — in-depth analysis.

EUDA (2025), European drug report 2025: trends and developments.

Favril, L., Yu, R., Hawton, K. and Fazel, S. (2020), ‘Risk factors for self-harm in prison: a systematic review and meta-analysis’, Lancet Psychiatry 7(8), pp. 682-691, doi:10.1016/S2215-0366(20)30190-5.

Fazel, S., Ramesh, T. and Hawton, K. (2017), ‘Suicide in prisons: an international study of prevalence and contributory factors’, Lancet Psychiatry 4(12), pp. 946-952, doi:10.1016/S2215-0366(17)30430-3.

Frischer, M., Baldacchino, A., Crome, I. and Bloor, R. (2012), Preventing opioid overdoses in Europe: a critical assessment of known risk factors and preventative measures, European Monitoring Centre for Drugs and Drug Addiction, Lisbon.

Gine, F., Donat, M., Guerras, J. M., Barrio, G., Belza, M. J., Politi, J. and Regidor, E. (2025), ‘Changing trends in drug overdose mortality in Spain, 2001-2022’, Addiction, doi:10.1111/add.70121.

Giraudon, I., Abel-Ollo, K., Vanaga-Arāja, D., Heudtlass, P. and Griffiths, P. (2024), ‘Nitazenes represent a growing threat to public health in Europe’, Lancet Public Health 9, E216, doi:10.1016/S2468-2667(24)00024-0.

Giraudon, I., Gallegos, A., Handanagic, S. and Mounteney, J. (2025), ‘Commentary on Bade et al.: Threat of nitazenes and other potent synthetic opioids-Is Europe prepared? Time to respond and to learn’, Addiction 120(9), pp. 1747-1748, doi:10.1111/add.70150.

Haro, B., Fernández-Montalvo, J., Arteaga, A. and López-Goñi, J. J. (2023), ‘Gender differences in patients with substance use disorder and physical/sexual abuse: a preliminary study’, Clínica y Salud 34(3), p. 9, doi:10.5093/clysa2023a12.

Jones, M. S., Worthen, M. G. F., Sharp, S. F. and McLeod, D. A. (2018), ‘Life as she knows it: the effects of adverse childhood experiences on intimate partner violence among women prisoners’, Child Abuse and Neglect 85(6), pp. 68-79, doi:10.1016/j.chiabu.2018.08.005.

Killeen, N., Lakes, R., Webster, M., Killoran, S., McNamara, S., Kavanagh, P., Eagleton, M., McCormack, S., et al. (2024), ‘The emergence of nitazenes on the Irish heroin market and national preparation for possible future outbreaks’, Addiction 119(9), pp. 1657-1658, doi:10.1111/add.16525.

Kostovski, E., Hamina, A., Hjellvik, V., Clausen, T. and Skurtveit, S. (2024), ‘Increased cancer incidence and mortality among people with opioid use-related disorders: a nation-wide cohort study’, Addiction 119(9), pp. 1575-1584, doi:10.1111/add.16524.

Kriikku, P., Pelander, A., Jylhä, A. and Ojanperä, I. (2025), ‘Post-mortem identification and toxicological findings of fluetonitazepyne and isotonitazepyne’, Drug Testing and Analysis, doi:10.1002/dta.3928.

Leifman, H. (2017), Drug-related deaths in Sweden: estimations of trends, effects of changes in recording practices and studies of drug patterns.

López-Pelayo, H., Vicente, V., Gallegos, A., McAuley, A., Büyük, Y., White, M. and Giraudon, I. (2021), ‘Mortality involving new psychoactive substances across Europe, 2016-2017’, Emerging Trends in Drugs, Addictions and Health 1(100016), doi:10.1016/j.etdah.2021.100016.

Montanari, L., Royuela, L., Mazzilli, S., Vandam, L., Alvarez, E., Llorens, N., Carapinha, L., Grohmannova, K., et al. (2024), ‘Prevalence of drug use before and during imprisonment in seven European countries (2014-2018)’, Journal of Community Psychology 52(8), pp. 1015-1030, doi:10.1002/jcop.23053.

Pavarin, R. M., Consonni, D., Lucchi, F., Pandolfi, P., Marani, S., Palmese, F. and Domenicali, M. (2023), ‘COVID-19-related death in patients with alcohol or substance use disorders’, European Addiction Research 29(1), pp. 67-70, doi:10.1159/000527542.

Peacock, A., Tran, L. T., Larney, S., Stockings, E., Santo, T., Jr., Jones, H., Santomauro, D. and Degenhardt, L. (2021), ‘All-cause and cause-specific mortality among people with regular or problematic cocaine use: a systematic review and meta-analysis’, Addiction 116(4), pp. 725-742, doi:10.1111/add.15239.

Pierce, M., Bird, S. M., Hickman, M., Marsden, J., Dunn, G., Jones, A. and Millar, T. (2016), ‘Impact of treatment for opioid dependence on fatal drug-related poisoning: a national cohort study in England’, Addiction 111(2), pp. 298-308, doi:10.1111/add.13193.

Ronka, S., Konttinen, H., Kriikku, P., Hakkarainen, P., Hakkinen, M. and Karjalainen, K. (2025), ‘Exploring the risk matrix of drug overdose deaths of young people: drug use patterns, individual characteristics, circumstances, and environment’, Drug and Alcohol Dependence 274, doi:10.1016/j.drugalcdep.2025.112757.

Rönkä, S., Konttinen, H., Häkkinen, M. and Karjalainen, K. (2024), ‘The circumstances of drug-poisoning deaths among young people: perspectives on prevention [Nuorten huumemyrkytyskuolemien olosuhteet – Näkökulmia ehkäisyyn]’, Study in Brief, THL, 24/2024, https://www.julkari.fi/handle/10024/149125.

Roussos, S., Angelopoulos, T., Cholongitas, E., Savvanis, S., Papadopoulos, N., Kapatais, A., Chounta, A., Ioannidou, P., et al. (2024), ‘High levels of all-cause mortality among people who inject drugs from 2018 to 2022’, International Journal of Drug Policy 126, doi:10.1016/j.drugpo.2024.104356.

Roxburgh, A., Sam, B., Kriikku, P., Mounteney, J., Castanera, A., Dias, M. and Giraudon, I. (2021), ‘Trends in MDMA-related mortality across four countries’, Addiction 116(11), pp. 3094-3103, doi:10.1111/add.15493.

Safety Investigation Authority (2024), Accidental drug-related deaths among young people in Finland in 2023.

Santo, T., Jr., Clark, B., Hickman, M., Grebely, J., Campbell, G., Sordo, L., Chen, A., Tran, L. T., et al. (2021), ‘Association of ppioid agonist treatment with all-cause mortality and specific causes of death among people with opioid dependence: a systematic review and meta-analysis’, JAMA Psychiatry 78(9), pp. 979-993, doi:10.1001/jamapsychiatry.2021.0976.

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Skeie, I., Clausen, T., Hjemsaeter, A. J., Landheim, A. S., Monsbakken, B., Thoresen, M. and Waal, H. (2022), ‘Mortality, causes of death, and predictors of death among patients on and off opioid agonist treatment: results from a 19-year cohort study’, European Addiction Research 28(5), pp. 358-367, doi:10.1159/000525694.

Torrens, M., Gilchrist, G. and Domingo-Salvany, A. (2011), ‘Psychiatric comorbidity in illicit drug users: substance-induced versus independent disorders’, Drug and Alcohol Dependence 113(2-3), pp. 147-156, doi:10.1016/j.drugalcdep.2010.07.013.

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Zlodre, J. and Fazel, S. (2012), ‘All-cause and external mortality in released prisoners: systematic review and meta-analysis’, American Journal of Public Health 102(12), pp. e67-e75, doi:10.2105/AJPH.2012.300764.

Source data

Links to all source data tables used in the report to create data visualisations may be found at the bottom of each chapter, as well as, in most cases, beneath each graphic. The entire source data set for the report, including data for tables which appear within the report, may be found using the link below. All data provided may be reused under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence. This means that reuse is allowed provided appropriate credit is given and any changes are indicated.

Complete set of source data tables for the Frequently asked questions (FAQ): drug-induced deaths in Europe.

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Recommended citation: European Union Drugs Agency (2025), Frequently asked questions (FAQ): drug-induced deaths in Europe, https://www.euda.europa.eu/publications/topic-overviews/drug-induced-deaths-faq_en


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